The toss play works well out of far set, you can sometimes surprise them with an inside run / fb dive out of those sets as well.
Also, I'm assuming you use the Chargers, so out of the far set twins in addition to running the pitch try running the sweep with Sproles (It goes the opposite direction, but Sproles can sometimes get around the corner and have a huge gain.)
PA passes work well out of those sets too, and there are a lot of other formations with strong running plays.