I've been using the saints 4-3 for a couple of months now, and like miked152 said you're gonna have to play a passive type of d. But, if you want to add pressure then i've found success usering grant and smith at the de to pass rush the qb. Vilma is extremely underrated at mlb, he does well in zones and rushing. And like halljam said if you user the safety go for sharper, and get a couple pick 6's.
the key for me has usually been zone blitzes and corner blitzes, the corners are pretty quick to the qb. hope that helps some