Yes lucky things can happen, and they do happen alot sometimes
but skill CAN overcome luck during the course of a game, it still just comes down to making the right moves during a game
a LB is making crazy plays? stay away from him
your RB keeps fumbling the ball? get out of bounds if your near the sideline
he keeps breaking alot of tackles? user each and every hit stick and he WILL go down
i have won plenty of games that i really shouldnt have won because i was able to forget and overcome all the lucky stuff the people i have played have had
so i would say 85% skill 15% luck