try avoid using 46 unless its like 3rd and 2 or 4th and 1, 46 is a much centered defensive spread making it easy to guess wrong and allow the opponent to run one to the house, best way to stop the run is choosing blitz plays from 4-3, then shifting and crashing your defensive lines toward the way the runner appears to be going, yes misdirections will kill you if your corner bails, but in most scenarios will get the job done.