have you tried putting the DEs and OLB in flat zones? or maybe even man coverage. some screens eat up man coverage, but some get shut down by man coverage. i know FL screens work good against man, but putting a DE in a flat zone can shut that down.
my main defense against screens is just user coverage. i user a MLB, and screens are easy to read AFTER the snap, you just have to be looking. as soon as you see those lineman head towards the flats, turbo your guy towards the receiver, right into him, and you should get a tackle as soon as he touches the ball.