I think this is when you can really take advantage of some nano's and blitzing. If the guy is running, then a run blitz should help stop him, and if he's using the PA, then the time spend on the fake should allow you to sack the QB pretty easily. Gotta load up the box and hope to put him into 2nd and long and 3rd and long. If you can do that and play a good game of field position, then you have a good chance, IMO. It's tough to run the ball 70-80 yards and get a TD.