Just go on instinct. But my favorite thing to use is the stiff arm.
Also, before you pick a run play, think about all the ways you can evade a tackle. Before you hit that hole, see if there is a cut back lane and usually, there is one DE or CB on the outside that can easily be trucked.
And sometimes in the open field, just use the quick burst juke, and if you are with a elusive back (Even ahmad bradshaw and tashard choice counts), always look for someone to evade. The ey is to move around alot and use the anolog every single sec
But if your with brandon jacobs or any power back, just Run down hill, and when you want to break a tackle, make sure you have a full head of steam. Make sure he is going full speed. Another thing is if you break one tackle, you usually get alot of momentum and you start breaking tackles left to right, once your in a situation like that, widen your veriety by stiffarming (Make sure your ball side is facing the bounds), and just flat out branching tackles by using the anolog stick to branch out once your tackled
And last, remember that the key to running the football is to not get hit and pic good running choices. But if your playing with a big time PowerBack (Not marshawn Lynch type) always look for someone to hit. Just think walter payton, hit them before they can hit you. But As a power back, dont rely on breaking alot of tackles, the goal is to push the pile and fall forward almost every play.