Here's 3 possibilities- all risky, but can be effective.
1- Come out in cover 1 or cover 0 man with a decent to heavy blitz and bump his receivers. You don't have to worry about a pass to the hb because there is none.
2- put an interior linebacker in spy if he's throwing over the middle slants. If he's waiting on them, try to con him into errantly throwing the wrong slant by using another underneath defender.. ending in a pick for you.
3-cover 2 buc out of dime... play the MLB.. watch his routes to see if he has one going deep mid. If not, sit middle and if he throws a slant it's a pick and if he throws to a sideline it'll be defended. The slants will be rendered ineffective, but a post or a slot streak can be the end of you.