Okay I'm hoping this might help a few of you around here.
-Open up your playbook, this will always keep the other player on there's toes.
-Have a good balance of run and pass, but if you see that the can't stop the ball run it!
-If having to choose between a speed QB and an accurate QB I'd go accurate but, if your have a heavy blitz on you, try the speed guy he can still throw a good ball every now and the on the run.
-Try getting passes off quickly when you see a man open.
-Step up in the pocket.
-Try and have at least one money play that you can go to in need of a big play, and make sure you don't use it much.
-Stay cool and clam when the game is on the line.(Be like Tom Brady lol)
Hope these help and feel free to add some of your own.