Running out of the spread is really hard.
If you wanna do it, you back has very little help, you you're gonna need to pass a few times for every run, just to keep the defense way spread out.
Also, find the formation you use most, and then put a run from that in your audibles, so that when the LB's spread you've got that play to switch to, and they won't see it coming.
Like a HB gut or HB draw out of your selected formation should work.