Like BRB said, have a TE either run in a flat, post/corner. If you have the TE in a flat, get your fastest(and tallest if possible) to run in a streak, or fade if you see fade would beat the man coverage (if man). Have your HB run on an opposite flat and have your FB run on a hitch. Now you won't have much time to get anything with no one blockin and nano's comin, so you need to get it off to the FB, TE, or RB. If he commits to the flats and is in cover 1, burn him with a streak.