u gotta try to predict what he is gonna come out with...but if that is his gameplan, use the 4-6 defense to shut down the run...or the 4-4 if u are familiar with the titans defensive pb at all(i think its more effective personally)...u should be able to stop LT with these...then, on the PA, control troy and manually cover sproles...does he use a dual HB set? if not, when u see sproles in, get ready for that play...but try not to be to predictable either...u want to catch him off guard...maybe show blitz out of a nickel formation, drop into a cover 1(with polamalu in man coverage, and the LB in zone over the middle), and try to jump Sproles route for pick 6...and for gates, dime defense...or, go into coverage assignments and put a fast CB on him manned up all game...cause from the sound of this guys play style, u are never gonna want to use a zone defense anyways...